INDUCTION OF TOLERANCE TO AN IGG AUTOANTIBODY

被引：74

作者：

OFFEN, D

SPATZ, L

ESCOWITZ, H

FACTOR, S

DIAMOND, B

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,BRONX,NY 10461

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 17期

关键词：

DOUBLE-STRANDED DNA ANTIBODY; B-CELL TOLERANCE; ANERGY; ALLELIC EXCLUSION;

D O I：

10.1073/pnas.89.17.8332

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this gamma-2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.

引用

页码：8332 / 8336

页数：5

共 36 条

[1] DETECTION OF NATIVE AND DENATURED DNA ANTIBODY-FORMING-CELLS BY THE ENZYME-LINKED IMMUNOSPOT ASSAY - A CLINICAL-STUDY OF (NEW-ZEALAND BLACK X NEW-ZEALAND WHITE)F1 MICE [J].