THE HYPERTRIGLYCERIDEMIC RAT AS A GENETIC MODEL OF HYPERTENSION AND DIABETES

被引：51

作者：

STOLBA, P

DOBESOVA, Z

HUSEK, P

OPLTOVA, H

ZICHA, J

VRANA, A

KUNES, J

机构：

[1] CZECHOSLOVAK ACAD SCI, INST PHYSIOL,VIDENSKA 1083, CS-14220 PRAGUE 4, CZECHOSLOVAKIA

[2] INST CLIN & EXPTL MED, CS-14622 PRAGUE 4, CZECHOSLOVAKIA

[3] INST ENDOCRINOL, PRAGUE, CZECHOSLOVAKIA

来源：

LIFE SCIENCES | 1992年 / 51卷 / 10期

关键词：

D O I：

10.1016/0024-3205(92)90482-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypertriglyceridemia was demonstrated in untreated hypertensive patients as well as in animals with genetic and experimental hypertension. The main purpose of the present study was to evaluate the possibility to use the hereditary hypertriglyceridemic (HTG) nonobese rats in hypertensive research. Direct measurement of blood pressure demonstrated significantly higher systolic, diastolic and mean arterial pressures in HTG rats in comparison with control Wistar rats. There was significant positive correlation between blood pressure and plasma triglyceride concentration (r = 0.585, n = 40, p < 0.001). In addition, there were significantly increased plasma norepinephrine and epinephrine concentrations in HTG rats, suggesting that the stimulation of sympathetic nervous system could be one of the pathogenetic mechanisms involved in the increase of blood pressure of HTG rats.

引用

页码：733 / 740

页数：8

共 26 条

[1] GLUCOSE-TOLERANCE AND INSULIN ACTION IN RATS WITH RENOVASCULAR HYPERTENSION [J].