EFFECTS OF LONG-TERM D-FENFLURAMINE TREATMENT ON ENERGY-METABOLISM IN RATS

被引:5
作者
BENTHEM, L [1 ]
SCHEURINK, AJW [1 ]
VANDERLEEST, J [1 ]
LEUVENINK, H [1 ]
ZIJLSTRA, WG [1 ]
STEFFENS, AB [1 ]
机构
[1] UNIV GRONINGEN, DEPT ANIM PHYSIOL, 9712 KZ GRONINGEN, NETHERLANDS
关键词
SEROTONERGIC MECHANISMS (PERIPHERAL); GLUCOSE; FREE FATTY ACIDS; INSULIN; CALORIMETRY (INDIRECT); EXERCISE; (RAT); (BASE-LINE CONDITIONS);
D O I
10.1016/0014-2999(93)90785-G
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of chronic intragastric administration of the anorectic agent d-fenfluramine on energy metabolism and nutrient concentrations were investigated at rest and during swimming. Rats were provided with permanent cannulas for blood sampling and intragastric administration of d-fenfluramine or saline. Energy expenditure and nutrient and hormone concentrations were determined. Under baseline conditions, d-fenfluramine increased carbohydrate utilization (14.2 vs. 7.0 mg/kg . min) and decreased fat oxidation (2.8 vs. 5.5 mg/kg . min). Plasma free fatty acid concentration was decreased (0.29 vs. 0.55 mmol/l) and lactate and insulin concentrations were increased after d-fenfluramine treatment (0.64 vs. 0.37 mmol/l and 61 vs. 33 mU/l, respectively). The shift in nutrient utilization also occurred during swimming. The exercise-induced increase in blood glucose was reduced after d-fenfluramine (+0.8 vs. +2.0 mmol/l). During swimming, free fatty acid, lactate and insulin concentrations were similar in the two groups. It is hypothesized that chronic d-fenfluramine treatment increases in the oxidation of carbohydrates and decreases the oxidation of fat as a result of a decrease in the transport of fatty acids over the mitochondrial membrane.
引用
收藏
页码:279 / 286
页数:8
相关论文
共 35 条
[1]   FENFLURAMINE AND GLUCOSE-UPTAKE BY MUSCLE [J].
BAJAJ, JS ;
VALLANCE.J .
HORMONE AND METABOLIC RESEARCH, 1974, 6 (01) :85-85
[2]   HYPERINSULINEMIA AND GLUCOSE-TOLERANCE IN OBESE RATS WITH LESIONS OF THE VENTROMEDIAL HYPOTHALAMUS - DEPENDENCE ON FOOD-INTAKE AND ROUTE OF ADMINISTRATION [J].
BALKAN, B ;
STEFFENS, AB ;
BRUGGINK, JE ;
STRUBBE, JH .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (10) :1092-1100
[3]   POSSIBLE RELATIONSHIPS BETWEEN CHANGES IN BODY-WEIGHT SET-POINT AND STRESS METABOLISM AFTER TREATING RATS CHRONICALLY WITH D-FENFLURAMINE - EFFECTS OF FEEDING RATS ACUTELY WITH FRUCTOSE ON THE METABOLISM OF CORTICOSTERONE, GLUCOSE, FATTY-ACIDS, GLYCEROL AND TRIACYLGLYCEROL [J].
BRINDLEY, DN ;
SAXTON, J ;
SHAHIDULLAH, H ;
ARMSTRONG, M .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (08) :1265-1271
[4]   DETERMINATION OF ENERGY-METABOLISM FROM RESPIRATORY FUNCTIONS ALONE [J].
BURSZTEIN, S ;
SAPHAR, P ;
GLASER, P ;
TAITELMAN, U ;
DEMYTTENAERE, S ;
NEDEY, R .
JOURNAL OF APPLIED PHYSIOLOGY, 1977, 42 (01) :117-119
[5]  
CARLSON LA, 1965, HANDB PHYSIOL, P625
[6]  
CARLTON J, 1989, INT J OBESITY, V13, P825
[7]  
DANNENBURG WN, 1970, AMPHETAMINES RELATED, P597
[8]   PLASMA-CATECHOLAMINE, CORTICOSTERONE AND GLUCOSE RESPONSES TO REPEATED STRESS IN RATS - EFFECT OF INTERSTRESSOR INTERVAL LENGTH [J].
DEBOER, SF ;
KOOPMANS, SJ ;
SLANGEN, JL ;
VANDERGUGTEN, J .
PHYSIOLOGY & BEHAVIOR, 1990, 47 (06) :1117-1124
[9]   METABOLIC MECHANISM OF THE ANORECTIC AND LEPTOGENIC EFFECTS OF THE SEROTONIN AGONIST FENFLURAMINE [J].
EVEN, P ;
NICOLAIDIS, S .
APPETITE, 1986, 7 :141-163
[10]   STIMULATION BY FENFLURAMINE OF GLUCOSE-UPTAKE INTO SKELETAL-MUSCLE IN-VITRO [J].
FRAYN, KN ;
HEDGES, A ;
KIRBY, MJ .
HORMONE AND METABOLIC RESEARCH, 1974, 6 (01) :86-86