EFFECTS OF ADRENOCEPTOR ANTAGONISTS ON THE HYPERTHERMIA AND HYPERGLYCEMIA-INDUCED BY PROSTAGLANDIN-F2-ALPHA IN RATS

被引：6

作者：

NONOGAKI, K ^{[1
]}

IGUCHI, A ^{[1
]}

SAKAMOTO, N ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT INTERNAL MED 3,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期

关键词：

PROSTAGLANDIN F2-ALPHA; ADRENOCEPTOR; HYPERGLYCEMIA; HYPERTHERMIA;

D O I：

10.1016/0014-2999(94)90043-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of intraperitoneal administration of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F-2 alpha (50 mu g) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostaglandin F-2 alpha. Prazosin inhibited the hyperthermia induced by prostaglandin F-2 alpha, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F-2 alpha-induced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F-2 alpha-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia induced by prostaglandin F-2 alpha is regulated by alpha(2)-adrenoceptor systems while the hyperthermia is regulated by alpha(1)-adrenoceptor systems in rats.

引用

页码：177 / 180

页数：4

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