TRANSFERRIN MICROHETEROGENEITY AS A PROBE IN NORMAL AND DISEASE STATES

被引：21

作者：

DEJONG, G

FEELDERS, R

VANNOORT, WL

VANEIJK, HG

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED,DEPT CHEM PATHOL,3000 DR ROTTERDAM,NETHERLANDS

[2] ERASMUS UNIV ROTTERDAM,ACAD HOSP ROTTERDAM DIJKZIGT,DEPT INTERNAL MED 2,3000 DR ROTTERDAM,NETHERLANDS

来源：

GLYCOCONJUGATE JOURNAL | 1995年 / 12卷 / 03期

关键词：

TRANSFERRIN MICROHETEROGENEITY; ISOELECTRIC FOCUSING; IRON SATURATED SERUM; CEREBROSPINAL FLUID LEAKAGE; ALCOHOL ABUSE; CARBOHYDRATE DEFICIENT GLYCOPROTEIN SYNDROME; N-GLYCOSYLATION;

D O I：

10.1007/BF00731323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebrospinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein syndrome. In normal physiological states it can also be used as a tool to probe for changes in N-glycosylation.

引用

页码：219 / 226

页数：8

共 24 条

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