DEPENDENCE OF POSITION-EFFECT VARIEGATION IN DROSOPHILA ON DOSE OF A GENE ENCODING AN UNUSUAL ZINC-FINGER PROTEIN

被引：225

作者：

REUTER, G

GIARRE, M

FARAH, J

GAUSZ, J

SPIERER, A

SPIERER, P

机构：

[1] UNIV GENEVA,DEPT MOLEC BIOL,CH-1211 GENEVA 4,SWITZERLAND

[2] BIOL RES CTR,INST GENET,H-6701 SZEGED,HUNGARY

来源：

NATURE | 1990年 / 344卷 / 6263期

关键词：

D O I：

10.1038/344219a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains. © 1990 Nature Publishing Group.

引用

页码：219 / 223

页数：5

共 35 条

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