AUTOCRINE EFFECT OF ENDOTHELIN ON DNA-SYNTHESIS IN HUMAN VASCULAR ENDOTHELIAL-CELLS

被引：70

作者：

TAKAGI, Y

FUKASE, M

TAKATA, S

YOSHIMI, H

TOKUNAGA, O

FUJITA, T

机构：

[1] NATL CARDIOVASC CTR HOSP & RES INST,SUITA,OSAKA 565,JAPAN

[2] SAGA MED SCH,DEPT PATHOL,SAGA 84001,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92354-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the role of endogenous endothelin on DNA synthesis in endothelial cells, we have investigated the effects of rabbit anti-ET γ globulin on DNA synthesis in cultured human vascular endothelial cells. DNA synthesis was markedly inhibited by anti-ET γ globulin in a concentration dependent manner in the presence of fetal calf serum(FCS) (x5000; 34%, x2500; 54%, x1000; 70%), but not in the absence of FCS. These data suggest that endogenous ET modulates FCS-stimulated DNA synthesis in an autocrine fashion. © 1990.

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页码：537 / 543

页数：7

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