SYNTHESIS OF OPTICALLY-ACTIVE ALPHA,ALPHA-DISUBSTITUTED BETA-KETO-ESTERS VIA CHIRAL BETA-ENAMINO ESTERS

被引：42

作者：

GUINGANT, A

HAMMAMI, H

机构：

[1] Unité de Chimie Organique associée au CNRS, ESPCI, 75231 Paris Cedex 05

来源：

TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 06期

关键词：

CHIRAL BETA-ENAMINO ESTERS; OPTICALLY ACTIVE BETA-KETO ESTERS; MICHAEL ADDITION; LEWIS ACID; HIGH PRESSURE;

D O I：

10.1016/S0957-4166(00)82164-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Michael addition of chiral beta-enamino esters to MVK and acrylates promoted by Lewis acids (ZnCl2, MgBr2) or high pressure (11-14 Kbar) afforded, after hydrolytic work-up, alpha,alpha-disubstituted beta-keto esters in good enantiomeric excesses.

引用

页码：411 / 414

页数：4

共 11 条

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