NUCLEOTIDE-SEQUENCE OF A COMPLEMENTARY-DNA FOR HUMAN ST2

被引：60

作者：

TOMINAGA, S ^{[1
]}

YOKOTA, T ^{[1
]}

YANAGISAWA, K ^{[1
]}

TSUKAMOTO, T ^{[1
]}

TAKAGI, T ^{[1
]}

TETSUKA, T ^{[1
]}

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT MOLEC BIOL,TOKYO 113,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1171卷 / 02期

关键词：

IMMUNOGLOBULIN SUPERFAMILY; INTERLEUKIN-1; RECEPTOR; CELL PROLIFERATION; T-CELL; CYTOKINE; CELL CYCLE; (HUMAN);

D O I：

10.1016/0167-4781(92)90125-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human ST2 cDNA, a homologue of murine ST2 that is only expressed in growth-stimulated BALB/c-3T3 cells and a member of the primary response gene family induced by growth factors, was isolated from the cDNA library of an activated human helper T cell line, 5C10. Human ST2 has 67.6% identity in a 327 amino acid overlap to murine ST2. Furthermore, as in the case of murine ST2, human ST2 encodes a protein remarkably similar in sequence to the extracellular portion of human interleukin 1 receptor, both types 1 and 2. The expression of ST2 in human lymphocytes could trigger further investigations into its physiological role in humans.

引用

页码：215 / 218

页数：4

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