A SIMPLE GENERAL-METHOD FOR CONVERSION OF FUNCTIONALIZED ESTERS TO FUNCTIONALIZED AMIDES

被引：12

作者：

RIVIEREBAUDET, M

MORERE, A

DIAS, M

机构：

[1] Laboratoire de chimie des Organominéraux, associé au CNRS, Université Paul Sabatier

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)79013-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and easy new method lor the conversion of amino-esters into amino-amides is described. In a one pot reaction between dialkyllithium amide and some amino-esters of thiophene and benzene, the corresponding amino-N-dialkylamides have been synthesized in high yields. The method was extended to malonic and phenylacetic esters. The reaction mechanism involves an anionic intermediate characterized by germylation.

引用

页码：6453 / 6456

页数：4

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