NONOXYNOL-9 PROTECTS MICE AGAINST VAGINAL TRANSMISSION OF GENITAL HERPES INFECTIONS

被引：39

作者：

WHALEY, KJ

BARRATT, RA

ZEITLIN, L

HOEN, TE

CONE, RA

机构：

[1] Department of Biophysics, Johns Hopkins University, Baltimore, MY

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 168卷 / 04期

关键词：

D O I：

10.1093/infdis/168.4.1009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provide significant protection against vaginal transmission of enveloped virus infections in animals.

引用

页码：1009 / 1011

页数：3

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