STRUCTURAL-ANALYSIS OF A CHELATING DERIVATIVE OF ALPHA-MELANOCYTE-STIMULATING HORMONE BY ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY

被引：1

作者：

DEVREESE, B

BARD, D

JACQUEMOTTE, F

VANBEEUMEN, J

机构：

[1] STRANGEWAYS RES LAB,CAMBRIDGE CB1 4RN,ENGLAND

[2] CERIA,MEURICE INST,DEPT NAT SCI,B-1070 BRUSSELS,BELGIUM

来源：

EUROPEAN MASS SPECTROMETRY | 1995年 / 1卷 / 03期

关键词：

ELECTROSPRAY MASS SPECTROMETRY; DEUTERIUM EXCHANGE; TARGETING; DIAGNOSTIC IMAGING; ALPHA-MELANOCYTE STIMULATING HORMONE; BISMSH-DTPA;

D O I：

10.1255/ejms.112

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The technique of electrospray ionisation mass spectrometry has been used to study the hydrogen/deuterium exchange of bisMSH-DTPA, a derivative of alpha-melanocyte stimulating hormone (MSH) in which two complete MSH peptide chains are covalently bound to a single molecule of diethylenetriamine pentaacetic acid (DTPA). The results show different levels of exchange between the metal-chelated and the unchelated peptide. We suggest that the unchelated peptide is able to form a hydrogen-bonded structure between the carboxyl groups of DTPA and the amino nitrogen of the N'-terminal serine of MSH.

引用

页码：301 / 304

页数：4

共 12 条

[1]

ALOBEIDI F, 1989, J AM CHEM SOC, V111, P3414

[2] A CHELATING DERIVATIVE OF ALPHA-MELANOCYTE STIMULATING HORMONE AS A POTENTIAL IMAGING AGENT FOR MALIGNANT-MELANOMA [J].