DEVELOPMENT OF NEW TECHNETIUM CORES CONTAINING TECHNETIUM NITROGEN MULTIPLE BONDS - SYNTHESIS AND CHARACTERIZATION OF SOME DIAZENIDO-COMPLEXES, HYDRAZIDO-COMPLEXES AND IMIDO-COMPLEXES OF TECHNETIUM

The syntheses of several novel diazenido-, hydrazido- and imido- complexes of technetium are described. These precursors which contain technetium-nitrogen multiple bonds are derived directly from the appropriate organohydrazine or amine in good yield. Some of the chemistry has been extended to the metastable isotope 99mTc (γ, t 1 2 = 6 h) in highly dilute aqueous media to give single species in high radiochemical purity. These preparations are applicable to the synthesis of new technetium radiopharmaceuticals and should provide for the development of a whole new range of technetium-based diagnostic agents in nuclear medicine. © 1990.