ANALYSIS OF CYTOLOGICAL CHANGES IN HEPATOCYTES FROM RATS DOSED WITH 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE - INITIAL RESPONSE APPEARS TO INVOLVE CYTOKINESIS OF BINUCLEATED CELLS

被引：8

作者：

KELLY, MD

STYLES, JA

PRITCHARD, NR

机构：

[1] ICI Central Toxicology Laboratories, Macclesfield, Cheshire SK10 4TJ, Alderley Park

来源：

CANCER LETTERS | 1990年 / 53卷 / 01期

关键词：

3′-methyl-4-dimethyl aminoazobenzene; binucleated; cytokines; cytological; hematocytes; rats;

D O I：

10.1016/0304-3835(90)90002-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The reduction in the ratio of tetraploid (4N + 2 × 2N) to diploid (2N) hepatocytes in the adult rat after treatment with the hepatocarcinogen 3′-methyl-4-dimethylaminoazobenzene (3′M) has been investigated. Analysis of isolated hepatocytes 18-28 days after treatment has confirmed that initially some of the 2 × 2N hepatocytes are converted into 2N cells by cytokinesis, and that there is no DNA synthesis during this process. Shortly afterwards non-polyploidizing growth commences by proliferation of some 2N cells. © 1990.

引用

页码：1 / 4

页数：4

共 19 条

[1] THE DEVELOPMENT OF POLYSOMATY IN RAT LIVER [J].