EVALUATION OF THE EFFECT OF DRUGS ON THE CYST FORM OF TOXOPLASMA-GONDII

被引：129

作者：

HUSKINSONMARK, J

ARAUJO, FG

REMINGTON, JS

机构：

[1] PALO ALTO MED RES FDN,RES INST,DEPT IMMUNOL & INFECT DIS,PALO ALTO,CA 94301

[2] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305

来源：

JOURNAL OF INFECTIOUS DISEASES | 1991年 / 164卷 / 01期

关键词：

D O I：

10.1093/infdis/164.1.170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80.

引用

页码：170 / 177

页数：8

共 20 条

[1]

ARAUJO FG, 1990, CLIN RES, V38, pA779

[2] AZITHROMYCIN, A MACROLIDE ANTIBIOTIC WITH POTENT ACTIVITY AGAINST TOXOPLASMA-GONDII [J].