INCREASE OF NITRIC-OXIDE PRODUCTION BY L-ARGININE POTENTIATES ICV ADMINISTERED BETA-ENDORPHIN-INDUCED ANTINOCICEPTION IN THE MOUSE

被引:50
作者
TSENG, LF
XU, JY
PIEPER, GM
机构
[1] Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
关键词
L-ARGININE; BETA-ENDORPHIN; ANTINOCICEPTION;
D O I
10.1016/0014-2999(92)90350-D
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pretreatment (i.c.v.) of mice with L-arginine but not D-arginine potentiated beta-endorphin-induced (i.c.v. administered) inhibition of the tail-flick response. The potentiation was attenuated by N(omega)-nitro-L-arginine methyl ester, a selective inhibitor of nitric oxide synthase. This observation suggests that increased production of nitric oxide from L-arginine mediates the potentiation of beta-endorphin-induced antinociception.
引用
收藏
页码:301 / 303
页数:3
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