THE COORDINATION OF COPPER(II) TO 1-HYDROXY-4-(GLYCYL-HISTIDYL-LYSINE)-ANTHRAQUINONE - A SYNTHETIC MODEL OF ANTHRAQUINONE ANTICANCER DRUGS

被引:8
作者
PETTIT, LD
UEDA, J
MORIERTEISSIER, E
HELBECQUE, N
BERNIER, JL
HENICHART, JP
KOZLOWSKI, H
机构
[1] INSERM,PL VERDUM,F-59045 LILLE,FRANCE
[2] UNIV LEEDS,SCH MED,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[3] UNIV WROCLAW,INST CHEM,PL-50137 WROCLAW,POLAND
关键词
D O I
10.1016/0162-0134(92)80045-W
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Results are reported of a pH-metric and spectroscopic (CD and ESR) study of the complexes formed between the pseudo-peptide 1-hydroxy-4-(Gly-His-Lys)-anthraquinone (Q-GHK) since, when complexed to copper ions, Q-GHK has been shown to be very effective in promoting the formation of free radicals and inducing DNA cleavage. Q-GHK forms very stable complexes with copper, the major species being bonded to three nitrogen donors in the coordination plane: an imidazole-N of the His residue and the peptide nitrogens of the Gly and His residues. This species is probably stabilized through bonding of the fourth planar coordination site of Cu(II) to the 9-anthraquinone oxygen. At high Q-GHK:copper ratios a second Q-GHK molecule is coordinated through its imidazole-N donor.
引用
收藏
页码:203 / 210
页数:8
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