UP-REGULATION OF ET(B)RECEPTOR SUBTYPE MESSENGER-RNA BY ANGIOTENSIN-II IN RAT CARDIOMYOCYTES

被引：60

作者：

KANNO, K

HIRATA, Y

TSUJINO, M

IMAI, T

SHICHIRI, M

ITO, H

MARUMO, F

机构：

[1] Tokyo Med and Dent Univ, Dept Internal Med 2, Div Endocrine Hypertens, Tokyo, 113

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of angiotensin (ANG) II on the expression of endothelin (ET) receptor subtype (ETA, ETB) mRNA in cultured neonatal rat cardiomyocytes was studied. ANG II (10-7 M) increased steady-state mRNA levels of ETB receptor, but not ETA receptor, during 6-12 hr incubation, whose effect was dose-dependent (10-9 - 10-7 M). ANG II receptor type-1 (AT1) antagonist (CV-11974) completely inhibited the ANG II-induced up-regulation of ETB receptor, whereas the inhibitory effect by ANG II receptor type-2 (AT2) antagonist (PD 123319) was incomplete. These results suggest that ANG II up-regulates cardiac ETB receptor, predominantly via AT1 receptor. © 1993 Academic Press. All rights reserved.

引用

收藏

页码：1282 / 1287

页数：6

相关论文

共 22 条

[1] CLONING AND EXPRESSION OF A CDNA-ENCODING AN ENDOTHELIN RECEPTOR [J].

ARAI, H ;

HORI, S ;

ARAMORI, I ;

OHKUBO, H ;

NAKANISHI, S .

NATURE, 1990, 348 (6303) :730-732

[2] ANGIOTENSIN-II STIMULATION OF PROTEIN-SYNTHESIS AND CELL-GROWTH IN CHICK HEART-CELLS [J].

BAKER, KM ;

ACETO, JF .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (02) :H610-H618

[3] NOMENCLATURE FOR ANGIOTENSIN RECEPTORS - A REPORT OF THE NOMENCLATURE-COMMITTEE OF THE COUNCIL-FOR-HIGH-BLOOD-PRESSURE-RESEARCH [J].

BUMPUS, FM ;

CATT, KJ ;

CHIU, AT ;

DEGASPARO, M ;

GOODFRIEND, T ;

HUSAIN, A ;

PEACH, MJ ;

TAYLOR, DG ;

TIMMERMANS, PBMWM .

HYPERTENSION, 1991, 17 (05) :720-721

[4]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[5] ENDOTHELIN RECEPTOR SUBTYPES ARE COUPLED TO ADENYLATE-CYCLASE VIA DIFFERENT GUANYL NUCLEOTIDE-BINDING PROTEINS IN VASCULATURE [J].

EGUCHI, S ;

HIRATA, Y ;

IMAI, T ;

MARUMO, F .

ENDOCRINOLOGY, 1993, 132 (02) :524-529

[6]

ELSHOURBAGY NA, 1993, J BIOL CHEM, V268, P3873

[7] VASCULAR SMOOTH-MUSCLE CELL HYPERTROPHY VS HYPERPLASIA - AUTOCRINE TRANSFORMING GROWTH FACTOR-BETA-1 EXPRESSION DETERMINES GROWTH-RESPONSE TO ANGIOTENSIN-II [J].

GIBBONS, GH ;

PRATT, RE ;

DZAU, VJ .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (02) :456-461

[8] DISTINCT TISSUE DISTRIBUTION AND CELLULAR-LOCALIZATION OF 2 MESSENGER RIBONUCLEIC-ACIDS ENCODING DIFFERENT SUBTYPES OF RAT ENDOTHELIN RECEPTORS [J].

HORI, S ;

KOMATSU, Y ;

SHIGEMOTO, R ;

MIZUNO, N ;

NAKANISHI, S .

ENDOCRINOLOGY, 1992, 130 (04) :1885-1895

[9] CONCOMITANT EXPRESSION OF RECEPTOR SUBTYPE AND ISOPEPTIDE OF ENDOTHELIN BY HUMAN ADRENAL-GLAND [J].

IMAI, T ;

HIRATA, Y ;

EGUCHI, S ;

KANNO, K ;

OHTA, K ;

EMORI, T ;

SAKAMOTO, A ;

YANAGISAWA, M ;

MASAKI, T ;

MARUMO, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 182 (03) :1115-1121

[10] THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES [J].

INOUE, A ;

YANAGISAWA, M ;

KIMURA, S ;

KASUYA, Y ;

MIYAUCHI, T ;

GOTO, K ;

MASAKI, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2863-2867