USE OF A BIPARTICLE FLUIDIZED-BED BIOREACTOR FOR THE CONTINUOUS AND SIMULTANEOUS FERMENTATION AND PURIFICATION OF LACTIC-ACID

被引:24
作者
KAUFMAN, EN
COOPER, SP
CLEMENT, SL
LITTLE, MH
机构
[1] Bioprocessing Research and Development Center, Oak Ridge National Laboratory, Oak Ridge, 37831-6226, TN
关键词
LACTIC ACID FERMENTATION; RESIN; ADSORBENT; BIPARTICLE FLUIDIZED BED; CONTINUOUS;
D O I
10.1007/BF02933462
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A continuous biparticle fluidized-bed reactor is developed for the simultaneous fermentation and purification of lactic acid. In this processing scheme, bacteria are immobilized in gelatin beads and are fluidized in a columnar reactor. Solid particles with sorbent capacity for the product are introduced at the top of the reactor, and fall counter currently to the biocatalyst, effecting in situ removal of the inhibitory product, while also controlling reactor pH at optimal levels. Initial long-term fermentation trials using immobilized Lactobacillus delbreuckii have demonstrated a 12-fold increase in volumetric productivity during absorbent addition as opposed to control fermentations in the same reactor. Unoptimized regeneration of the loaded sorbent has effected at least an eightfold concentration of lactic acid and a 68-fold enhancement in separation from glucose compared to original levels in the fermentation broth. The benefits of this reactor system as opposed to conventional batch fermentation are discussed in terms of productivity and process economics.
引用
收藏
页码:605 / 620
页数:16
相关论文
共 43 条
[1]   A FLUIDIZED-BED CONTINUOUS BIOREACTOR FOR LACTIC-ACID PRODUCTION [J].
ANDREWS, GF ;
FONTA, JP .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1989, 20-1 :375-390
[2]  
Atkinson B, 1991, BIOCH ENG BIOTECHNOL
[3]  
BUCHTA K, 1983, BIOTECHNOLOGY COMPRE
[4]   OPERABILITY AND FEASIBILITY OF ETHANOL-PRODUCTION BY IMMOBILIZED ZYMOMONAS-MOBILIS IN A FLUIDIZED-BED BIOREACTOR [J].
DAVISON, BH ;
SCOTT, CD .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1988, 18 :19-34
[5]   SIMULTANEOUS FERMENTATION AND SEPARATION OF LACTIC-ACID IN A BIPARTICLE FLUIDIZED-BED BIOREACTOR [J].
DAVISON, BH ;
THOMPSON, JE .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1992, 34-5 :431-439
[6]   A PROPOSED BIPARTICLE FLUIDIZED-BED FOR LACTIC-ACID FERMENTATION AND SIMULTANEOUS ADSORPTION [J].
DAVISON, BH ;
SCOTT, CD .
BIOTECHNOLOGY AND BIOENGINEERING, 1992, 39 (03) :365-368
[7]  
DONG GQ, 1992, APPL MICROBIOL BIOT, V37, P305, DOI 10.1007/BF00210983
[8]   RECOVERY OF LACTIC-ACID BY SORPTION - RESIN EVALUATION [J].
EVANGELISTA, RL ;
MANGOLD, AJ ;
NIKOLOV, ZL .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1994, 45-6 :131-144
[9]   FLUIDIZED-BED ADSORPTION FOR WHOLE BROTH EXTRACTION [J].
GAILLIOT, FP ;
GLEASON, C ;
WILSON, JJ ;
ZWARICK, J .
BIOTECHNOLOGY PROGRESS, 1990, 6 (05) :370-375
[10]   STRATEGIES FOR THE RECOVERY OF CHEMICALS FROM FERMENTATION - A REVIEW OF THE USE OF POLYMERIC ADSORBENTS [J].
GARCIA, AA .
BIOTECHNOLOGY PROGRESS, 1991, 7 (01) :33-42