DNA DAMAGES PROCESSED BY BASE EXCISION-REPAIR - BIOLOGICAL CONSEQUENCES

被引：137

作者：

WALLACE, SS

机构：

[1] Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Stafford Hall, Burlington, VT

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1994年 / 66卷 / 05期

关键词：

D O I：

10.1080/09553009414551661

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Base damages, sugar damages, and single-strand breaks produced by free radicals are the preponderant lesions produced in DNA by ionizing radiation. These lesions have been individually introduced into substrate, template, and biologically active DNA molecules and enzymatic processing and biological consequences determined. Free radical-induced DNA lesions are processed by base excision repair and many are potentially lethal in simple viral systems. Furthermore, a number of free radical modifications of purine and pyrimidine bases are premutagenic lesions. The results of the enzymatic and biological processing of a number of the more well-studied and stable lesions are summarized.

引用

页码：579 / 589

页数：11

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