MYASTHENIA-GRAVIS - AN AUTOIMMUNE-RESPONSE AGAINST THE ACETYLCHOLINE-RECEPTOR

被引:25
作者
GRAUS, YMF
DEBAETS, MH
机构
[1] Department of Immunology, University of Limburg, Maastricht, NL-6200 MD
关键词
MYASTHENIA GRAVIS; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; ACETYLCHOLINE RECEPTOR;
D O I
10.1007/BF02918370
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Myasthenia gravis (MG) is an organ-specific autoimmune disease caused by an antibody-mediated assault on the muscle nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. Binding of antibodies to the AChR leads to loss of functional AChRs and impairs the neuromuscular signal transmission, resulting in muscular weakness. Although a great deal of information on the immunopathological mechanisms involved in AChR destruction exists due to well-characterized animal models, it is not known which etiological factors determine the susceptibility for the disease. This review gives an overview of the literature on the AChR, MG and experimental models for this autoimmune disease.
引用
收藏
页码:78 / 100
页数:23
相关论文
共 275 条
[1]   ACETYLCHOLINE-RECEPTOR KINETICS [J].
ADAMS, PR .
JOURNAL OF MEMBRANE BIOLOGY, 1981, 58 (03) :161-174
[2]   SERUM GLOBULIN IN MYASTHENIA-GRAVIS - INHIBITION OF ALPHA-BUNGAROTOXIN BINDING TO ACETYLCHOLINE RECEPTORS [J].
ALMON, RR ;
ANDREW, CG ;
APPEL, SH .
SCIENCE, 1974, 186 (4158) :55-57
[3]   ATTEMPTS TO IMPLICATE VIRUSES IN MYASTHENIA-GRAVIS [J].
AOKI, T ;
DRACHMAN, DB ;
ASHER, DM ;
GIBBS, CJ ;
BAHMANYAR, S ;
WOLINSKY, JS .
NEUROLOGY, 1985, 35 (02) :185-192
[4]   ACCELERATED DEGRADATION OF ACETYLCHOLINE-RECEPTOR FROM CULTURED RAT MYOTUBES WITH MYASTHENIA-GRAVIS SERA AND GLOBULINS [J].
APPEL, SH ;
ANWYL, R ;
MCADAMS, MW ;
ELIAS, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (05) :2130-2134
[5]   INTERACTION OF MYASTHENIC IMMUNOGLOBULINS AND CHOLINERGIC AGONISTS ON ACETYLCHOLINE-RECEPTORS OF RAT MYOTUBES [J].
ASHIZAWA, T ;
ELIAS, SB ;
APPEL, SH .
ANNALS OF NEUROLOGY, 1982, 11 (01) :22-27
[6]   COMPLEMENT-DEPENDENT LYSIS OF CULTURED RAT MYOTUBES BY MYASTHENIC IMMUNOGLOBULINS [J].
ASHIZAWA, T ;
APPEL, SH .
NEUROLOGY, 1985, 35 (12) :1748-1753
[7]  
BARKAS T, 1988, J BIOL CHEM, V263, P5916
[8]   MAPPING THE MAIN IMMUNOGENIC REGION AND TOXIN-BINDING SITE OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR [J].
BARKAS, T ;
MAURON, A ;
ROTH, B ;
ALLIOD, C ;
TZARTOS, SJ ;
BALLIVET, M .
SCIENCE, 1987, 235 (4784) :77-80
[9]   NUCLEOTIDE-SEQUENCE OF HUMAN-MUSCLE ACETYLCHOLINE-RECEPTOR BETA-SUBUNIT [J].
BEESON, D ;
BRYDSON, M ;
NEWSOMDAVIS, J .
NUCLEIC ACIDS RESEARCH, 1989, 17 (11) :4391-4391
[10]   HUMAN-MUSCLE ACETYLCHOLINE-RECEPTOR - CLONING AND EXPRESSION IN ESCHERICHIA-COLI OF CDNA FOR THE ALPHA-SUBUNIT [J].
BEESON, D ;
BRYDSON, M ;
WOOD, H ;
VINCENT, A ;
NEWSOMDAVIS, J .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1989, 17 (01) :219-220