GLUCAGON-LIKE PEPTIDE-1(7-36)AMIDE SUPPRESSES GLUCAGON-SECRETION AND DECREASES CYCLIC-AMP CONCENTRATION IN CULTURED IN-R1-G9 CELLS

被引：19

作者：

MATSUMURA, T ^{[1
]}

ITOH, H ^{[1
]}

WATANABE, N ^{[1
]}

ODA, Y ^{[1
]}

TANAKA, M ^{[1
]}

NAMBA, M ^{[1
]}

KONO, N ^{[1
]}

MATSUYAMA, T ^{[1
]}

KOMATSU, R ^{[1
]}

MATSUZAWA, Y ^{[1
]}

机构：

[1] NATL CARDIOVASC CTR HOSP & RES INST,DEPT MED,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80836-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously reported that GLP-1(7-36)amide had glucagonostatic action as well as insulinotropic action in the perfused rat pancreas. In this study, we examined the effect of GLP-1(7-36)amide on glucagon secretion and cAMP concentration in glucagon-secreting cell line, In-Rl-G9. GLP-1(7-36)amide (1nM) significantly suppressed glucagon secretion and decreased cAMP concentration in the cells. GLP-1(1-37) did not affect glucagon secretion. It is suggested that inhibitory effect of GLP-1(7-36)amide on glucagon secretion is at least partly mediated by adenylate cyclase system. © 1992 Academic Press, Inc.

引用

页码：503 / 508

页数：6

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