THE ROLE OF IG-BETA IN PRECURSOR B-CELL TRANSITION AND ALLELIC EXCLUSION

被引：122

作者：

PAPAVASILIOU, F

MISULOVIN, Z

SUH, HK

NUSSENZWEIG, MC

机构：

[1] ROCKEFELLER UNIV, MOLEC IMMUNOL LAB, NEW YORK, NY 10021 USA

[2] ROCKEFELLER UNIV, HOWARD HUGHES MED INST, NEW YORK, NY 10021 USA

来源：

SCIENCE | 1995年 / 268卷 / 5209期

关键词：

D O I：

10.1126/science.7716544

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lymphocytes express multicomponent receptor complexes that mediate diverse antigen-dependent and antigen-independent responses. Despite the central role of antigen-independent events in B cell development, little is known about the mechanisms by which they are initiated. The association between the membrane immunoglobulin (Ig) M heavy chain (m mu) and the Ig alpha-Ig beta heterodimer is now shown to be essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion in transgenic mice. The cytoplasmic domain of Ig beta is sufficient to induce these early antigen-independent events by a mechanism that requires conserved tyrosine residues in this protein.

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页码：408 / 411

页数：4

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