REPRODUCTIVE HORMONES MODULATE ANGIOTENSIN-II AT1 RECEPTORS IN THE DORSOMEDIAL ARCUATE NUCLEUS OF THE FEMALE RAT

被引：30

作者：

SELTZER, A ^{[1
]}

TSUTSUMI, K ^{[1
]}

SHIGEMATSU, K ^{[1
]}

SAAVEDRA, JM ^{[1
]}

机构：

[1] NIMH, CLIN SCI LAB,PHARMACOL SECT,BLDG 10,ROOM 20-45, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA

来源：

ENDOCRINOLOGY | 1993年 / 133卷 / 02期

关键词：

D O I：

10.1210/en.133.2.939

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin II AT1 receptors are highly localized in the dorsomedial arcuate nucleus. AT1 receptor number is very low during proestrus and in ovariectomized and male rats, and is high only during the estrus phase of the estrous cycle and after ovariectomized rats receive a sequential estrogen-progesterone treatment. Our results suggest that the mechanism of the estrogen-progesterone inhibition of the prolactin surge may involve the selective stimulation of dorsomedial arcuate AT1 receptors.

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页码：939 / 941

页数：3

相关论文

共 16 条

[1] DOPAMINE IN HYPOPHYSEAL PORTAL PLASMA OF RAT DURING ESTROUS-CYCLE AND THROUGHOUT PREGNANCY [J].

BENJONATHAN, N ;

OLIVER, C ;

WEINER, HJ ;

MICAL, RS ;

PORTER, JC .

ENDOCRINOLOGY, 1977, 100 (02) :452-458

[2] STIMULATION OF DOPAMINE RELEASE INTO HYPOPHYSEAL PORTAL BLOOD BY ADMINISTRATION OF PROGESTERONE [J].

CRAMER, OM ;

PARKER, CR ;

PORTER, JC .

ENDOCRINOLOGY, 1979, 105 (04) :929-933

[3]

EVERITT BJ, 1992, NEUROENDOCRINOLOGY, P88

[4]

INOUE T, 1989, Society for Neuroscience Abstracts, V15, P724

[5] IMMUNOCYTOCHEMICAL COLOCALIZATION OF HYPOTHALAMIC PROGESTIN RECEPTORS AND TYROSINE-HYDROXYLASE IN STEROID-TREATED MONKEYS [J].

KOHAMA, SG ;

FREESH, F ;

BETHEA, CL .

ENDOCRINOLOGY, 1992, 131 (01) :509-517

[6] THE BRAIN RENIN-ANGIOTENSIN SYSTEM AND THE REGULATION OF PROLACTIN SECRETION IN FEMALE RATS - INFLUENCE OF OVARIAN HORMONES [J].

MYERS, LS ;

STEELE, MK .

JOURNAL OF NEUROENDOCRINOLOGY, 1989, 1 (04) :299-303

[7] THE BRAIN RENIN-ANGIOTENSIN SYSTEM AND PROLACTIN SECRETION IN THE MALE-RAT [J].

MYERS, LS ;

STEELE, MK .

ENDOCRINOLOGY, 1991, 129 (04) :1744-1748

[8] CALIBRATION OF I-125 POLYMER STANDARDS WITH I-125 BRAIN PASTE STANDARDS FOR USE IN QUANTITATIVE RECEPTOR AUTORADIOGRAPHY [J].

NAZARALI, AJ ;

GUTKIND, JS ;

SAAVEDRA, JM .

JOURNAL OF NEUROSCIENCE METHODS, 1989, 30 (03) :247-253

[9]

Paxinos G., 1986, BRAIN NAVIGATOR, Vsecond

[10] NEGATIVE FEEDBACK EFFECTS OF PROGESTERONE CORRELATED WITH CHANGES IN HYPOTHALAMIC NOREPINEPHRINE AND DOPAMINE TURNOVER RATES, MEDIAN-EMINENCE LUTEINIZING-HORMONE-RELEASING HORMONE, AND PERIPHERAL PLASMA GONADOTROPINS [J].

RANCE, N ;

WISE, RM ;

BARRACLOUGH, CA .

ENDOCRINOLOGY, 1981, 108 (06) :2194-2199