GROWTH-HORMONE DOES NOT INHIBIT ITS OWN SECRETION DURING PROLONGED HYPOGLYCEMIA IN MAN

被引:9
作者
BARBETTI, F
CRESCENTI, C
NEGRI, M
LEONETTI, F
GROSSI, A
TAMBURRANO, G
机构
[1] UNIV ROME LA SAPIENZA, CATTEDRA ENDOCRINOL 1, I-00185 ROME, ITALY
[2] UNIV ROME LA SAPIENZA, IST CLIN MED 2, I-00185 ROME, ITALY
关键词
D O I
10.1210/jcem-70-5-1371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In man, continuous infusion of GH-releasing hormone (GHRH) does not sustain GH secretion, unlike prolonged hypoglycemia. To further evaluate this difference in the stimulation of GH release we measured GH concentrations for 3 h during prolonged insulin-induced hypoglycemia and GHRH-(1–29)NH2 (100 μg/h) infusion in normal individuals. We also assessed the GH response to combined and separate administration of insulin and GHRH. Plasma GH levels increased during prolonged hypoglycemia and remained elevated for the third hour (22–24 μg/L). GH concentrations increased during GHRH infusion, peaked at 60 min (23.5 μg/L), and rapidly declined. Thus, our findings confirmed that prolonged hypoglycemia, unlike GHRH infusion, sustained elevated GH levels and that these high levels did not appear to influence GH secretion from the pituitary. Changes in FFA did not account for the sustained GH secretion. FFA levels initially declined during insulin infusion, but after 3 h of hypoglycemia they returned to near-basal values (basal, 0.1 ± 0.02 g/L; 180 min, 0.09 ± 0.02). The maximal GH concentration attained during the combined insulin and GHRH test was significantly higher than that with the insulin tolerance test or GHRH test (insulin plus GHRH, 71.9 ± 13.5; insulin tolerance test, 34.2 ± 2.9; P < 0.025; GHRH test, 27.9 ± 3.2; P < 0.02), indicating an additive effect on GH secretion. These data suggest that insulin-induced hypoglycemia stimulates GH secretion through a mechanism partly independent of GHRH. The release from somatostatin inhibition and stimulation through other neuropeptides (e.g. galanin) is suggested as possible causes of hypoglycemia-induced GH secretion. © 1990 by The Endocrine Society.
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页码:1371 / 1374
页数:4
相关论文
共 18 条
[1]   INSULIN, GLUCAGON AND GROWTH-HORMONE IN PRIMARY ADULT MYXEDEMA [J].
ANDREANI, D ;
FALLUCCA, F ;
TAMBURRANO, G ;
IAVICOLI, M ;
MENZINGER, G .
DIABETOLOGIA, 1974, 10 (01) :7-12
[2]   THE EFFECTS OF GROWTH-HORMONE (GH)-RELEASING PEPTIDES ON GH SECRETION IN PERIFUSED PITUITARY-CELLS OF ADULT MALE-RATS [J].
BADGER, TM ;
MILLARD, WJ ;
MCCORMICK, GF ;
BOWERS, CY ;
MARTIN, JB .
ENDOCRINOLOGY, 1984, 115 (04) :1432-1438
[3]   RELEASE OF SOMATOSTATIN-LIKE IMMUNOREACTIVITY FROM INCUBATED RAT HYPOTHALAMUS AND CEREBRAL-CORTEX - EFFECTS OF GLUCOSE AND GLUCOREGULATORY HORMONES [J].
BERELOWITZ, M ;
DUDLAK, D ;
FROHMAN, LA .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (06) :1293-1301
[4]   GROWTH-HORMONE (GH) RELEASE IN RESPONSE TO GH-RELEASING HORMONE IN MAN IS 3-FOLD ENHANCED BY GALANIN [J].
DAVIS, TME ;
BURRIN, JM ;
BLOOM, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (06) :1248-1252
[5]   COMPARISON OF GLUCOSE COUNTERREGULATION DURING SHORT-TERM AND PROLONGED HYPOGLYCEMIA IN NORMAL HUMANS [J].
DEFEO, P ;
PERRIELLO, G ;
DECOSMO, S ;
VENTURA, MM ;
CAMPBELL, PJ ;
BRUNETTI, P ;
GERICH, JE ;
BOLLI, GB .
DIABETES, 1986, 35 (05) :563-569
[6]   DOSE-RESPONSE RELATIONSHIPS FOR THE EFFECTS OF GROWTH HORMONE-RELEASING FACTOR-(1-44)-NH2 IN YOUNG-ADULT MEN AND WOMEN [J].
GELATO, MC ;
PESCOVITZ, OH ;
CASSORLA, F ;
LORIAUX, DL ;
MERRIAM, GR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 59 (02) :197-201
[7]   GROWTH-HORMONE RESPONSES TO CONTINUOUS INFUSIONS OF GROWTH HORMONE-RELEASING HORMONE [J].
GELATO, MC ;
RITTMASTER, RS ;
PESCOVITZ, OH ;
NICOLETTI, MC ;
NIXON, WE ;
DAGATA, R ;
LORIAUX, DL ;
MERRIAM, GR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (02) :223-228
[8]   THE EFFECT OF FREE FATTY-ACIDS ON GROWTH-HORMONE (GH)-RELEASING HORMONE-MEDIATED GH SECRETION IN MAN [J].
IMAKI, T ;
SHIBASAKI, T ;
SHIZUME, K ;
MASUDA, A ;
HOTTA, M ;
KIYOSAWA, Y ;
JIBIKI, K ;
DEMURA, H ;
TSUSHIMA, T ;
LING, N .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (02) :290-293
[9]  
LANZI R, 1989, 71ST P ANN M END SOC, P222
[10]   GROWTH-HORMONE RELEASING-FACTOR INFUSION DOES NOT SUSTAIN ELEVATED GH-LEVELS IN NORMAL SUBJECTS [J].
LOSA, M ;
BOCK, L ;
SCHOPOHL, J ;
STALLA, GK ;
MULLER, OA ;
VONWERDER, K .
ACTA ENDOCRINOLOGICA, 1984, 107 (04) :462-470