APPEARANCE OF THE T-CELL MARKER CD8 ON B-CHRONIC LYMPHATIC-LEUKEMIA CELLS IN LONG-TERM CULTURES

被引：8

作者：

FARKAS, R

BENEFRAIM, S

MANOR, Y

ZANBAR, I

KLAJMAN, A ^{[1
]}

机构：

[1] MEIR HOSP,CLIN IMMUNOL LAB,IL-44281 KEFAR SAVA,ISRAEL

[2] MEIR HOSP,DEPT HUMAN MICROBIOL,IL-44281 KEFAR SAVA,ISRAEL

[3] MEIR HOSP,DEPT HEMATOL,IL-44281 KEFAR SAVA,ISRAEL

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 1991年 / 34卷 / 03期

关键词：

T-CELL; CD8; MARKER; B-CELL LEUKEMIA;

D O I：

10.1007/BF01742310

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

引用

页码：181 / 185

页数：5

共 25 条

[1] MALIGNANT-LYMPHOMA WITH DUAL B-CELL AND T-CELL MARKERS - ANALYSIS OF THE NEOPLASTIC-CELLS WITH MONOCLONAL-ANTIBODIES DIRECTED AGAINST T-CELL SUBSETS [J].