EFFECTS OF DOPAMINE AGONIST, BROMOCRIPTINE, AND SOME DOPAMINE ANTAGONISTS ON OCULAR BLOOD-FLOW

被引：29

作者：

CHIOU, GCY

CHEN, YJ

机构：

[1] Institute of Ocular Pharmacology, Department of Pharmacology and Toxicology, Texas A&M University College of Medicine, College Station, Texas

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1992年 / 8卷 / 04期

关键词：

D O I：

10.1089/jop.1992.8.285

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A dopamine agonist, bromocriptine, and several dopamine antagonists, domperidone, haloperidol, floropipamide and chlofluperol, were studied for their effects on the ocular blood flow. Both domperidone and haloperidol are ocular hypotensive agents and are able to increase the ocular blood flow significantly. Floropipamide had little effect on the intraocular pressure (IOP) , yet it reduced the ocular blood flow markedly. Chlofluperol is an ocular hypertensive agent, yet it increased the ocular blood flow significantly. Although bromocriptine lowered the IOP, it did not affect the ocular blood flow. These results indicate that the changes of ocular blood flow are independent of the changes of the IOP. Therefore, it is critical to develop antiglaucoma agents which can increase retinal and choroidal blood flow in addition to lowering the IOP.

引用

页码：285 / 294

页数：10

共 18 条

[1]

Weinreb R., Glaucoma: Early diagnosis, better treatment, Eye Research Seminar. Research to Prevent Blindness, pp. 14-15, (1990)

[2]

Chandler P.A., Grant W.M., Progressive low-tension glaucoma, Glaucoma. Lea & Febiger, pp. 111-115, (1965)

[3]

Chiou G.C.Y., Yan H.Y., Effects of antigaaucoma drugs on the blood flow in rabbit eyes, Ophth. Res, 18, pp. 265-269, (1986)

[4]

Yan H.Y., Chiou G.C.Y., Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method, Ophth. Res, 19, pp. 45-48, (1987)

[5]

Martin X.D., Rabineau P.A., Vasoconstrictive effect of topical timolol on human retinal arteries, Graefe's Arch. Clin. Exp. Ophthalmol, 227, pp. 526-530, (1989)

[6]

Colloton E., Perkins E.S., The effect of timolol on the intraocular pulse pressure, Inv. Ophthalmol. Vis. Sci. Suppl, 27, (1986)

[7]

Mekki Q.A., Hassan S.M., Turner P., Bromocriptine lowers intraocular pressure without affecting blood pressure, Lancet, 1, pp. 1250-1251, (1983)

[8]

Mekki Q.A., Turner P., Stimulation of dopamine receptors (type 2) lowers human intraocular pressure, Brit. J. Ophthalmol, 69, pp. 909-910, (1985)

[9]

Mekki Q.A., Warrington S.J., Turner P., Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels, Lancet, 1, pp. 287-288, (1984)

[10]

Chiou G.C.Y., Ocular hypotensive actions of haloperidol, a dopaminergic antagonist, Arch. Ophthalmol, 102, pp. 143-145, (1984)

← 1 2 →