ANTINEOPLASTIC AGENTS .325. ISOLATION AND STRUCTURE OF THE HUMAN CANCER CELL-GROWTH INHIBITORY CYCLIC OCTAPEPTIDES PHAKELLISTATIN-10 AND PHAKELLISTATIN-11 FROM PHAKELLIA SP

被引：58

作者：

PETTIT, GR

TAN, R

ICHIHARA, Y

WILLIAMS, MD

DOUBEK, DL

TACKETT, LP

SCHMIDT, JM

CERNY, RL

BOYD, MR

HOOPER, JNA

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] UNIV NEBRASKA,MIDWEST CTR MASS SPECT,DEPT CHEM,LINCOLN,NE 68588

[3] NCI,FREDERICK CANC RES & DEV CTR,DIV CANC TREATMENT,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 06期

关键词：

D O I：

10.1021/np50120a025

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED(50) values of 2.1 and 0.20 mu g/ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D H-1- and C-13-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

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页码：961 / 965

页数：5

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