HUMAN PAPILLOMAVIRUS TYPE-18 DNA AND E6-E7 MESSENGER-RNA ARE DETECTED IN SQUAMOUS-CELL CARCINOMA AND ADENOCARCINOMA OF THE LUNG

被引：58

作者：

KINOSHITA, I

DOSAKAAKITA, H

SHINDOH, M

FUJINO, M

AKIE, K

KATO, M

FUJINAGA, K

KAWAKAMI, Y

机构：

[1] HOKKAIDO UNIV, SCH MED, DEPT MED 1, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

[2] HOKKAIDO UNIV, SCH DENT, DEPT ORAL PATHOL, SAPPORO, HOKKAIDO 060, JAPAN

[3] SAPPORO MED UNIV, CANC RES INST, DEPT BIOL MOLEC, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 02期

关键词：

HPV; LUNG CANCER; PCR; ISH;

D O I：

10.1038/bjc.1995.69

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To provide an accurate evaluation of the association of human papillomavirus (HPV) with lung cancer, 36 cases of lung cancer were analysed for HPV DNAs by polymerase chain reaction (PCR) with dot-blot and Southern blot analyses, and for the transcripts from the E6-E7 transforming region by in situ hybridisation (ISH). HPV-18 DNA was detected in three (8%) of 36 specimens; histologically, in one (10%) of 10 squamous cell carcinomas and two (9%) of 22 adenocarcinomas. Neither HPV-16 nor -33 DNA was detected in any cases examined. Expression of E6-E7 mRNA was confirmed in the cases which contained HPV-18 DNA. HPV-18 may play an important role in the development and progression of cancer in some cases of both squamous cell carcinoma and adenocarcinoma of the lung.

引用

页码：344 / 349

页数：6

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[1] RAS GENE-MUTATIONS AND HPV INFECTION ARE COMMON IN HUMAN LARYNGEAL CARCINOMA [J].