STIMULATION OF CELL-PROLIFERATION AND AUTOREGULATION OF ELASTIN EXPRESSION BY ELASTIN PEPTIDE VPGVG IN CULTURED CHICK VASCULAR SMOOTH-MUSCLE CELLS

被引：51

作者：

WACHI, H

SEYAMA, Y

YAMASHITA, S

SUGANAMI, H

UEMURA, Y

OKAMOTO, K

YAMADA, H

TAJIMA, S

机构：

[1] KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,TOKYO 160,JAPAN

[2] HOSHI COLL PHARM,DEPT CLIN CHEM,SHINAGAWA KU,2-4-41 EBARA,TOKYO 142,JAPAN

[3] KYUSHU INST TECHNOL,DEPT BIOCHEM ENGN & SCI,IIZUKA,FUKUOKA 820,JAPAN

来源：

FEBS LETTERS | 1995年 / 368卷 / 02期

关键词：

ELASTIN FRAGMENT; ELASTIN SYNTHESIS; SMOOTH MUSCLE CELL;

D O I：

10.1016/0014-5793(95)00641-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic elastin peptides, VPGVG or its polymer (VPGVG)(n), enhanced the proliferation of smooth muscle cells 1.5-fold during 48 h treatment at the concetrations over 10(-6) M or 1.0 mu g/ml, respectively, Monomeric and polymeric VPGVG sequences reduced elastin synthesis and its mRNA level to one-third and one-half of control respectively under the conditions in which the proliferation of cells,were enhanced, but did not change collagen synthesis as measured by bacterial collagenase digestion, The elastin-specific autoregulation by elastin fragments may reflect the feedback regulation of elastin expression which may play an essential role in elastin metabolism under the normal and diseased conditions.

引用

页码：215 / 219

页数：5

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