MONOKINE PRODUCTION BY MALNOURISHED NURSING-HOME PATIENTS

被引：12

作者：

BRADLEY, SF

VIBHAGOOL, A

FABRICK, S

TERPENNING, MS

KAUFFMAN, CA

机构：

[1] VET ADM MED CTR, DEPT INTERNAL MED, DIV INFECT DIS & IMMUNOL, INFECT DIS & IMMUNOL SECT, ANN ARBOR, MI 48105 USA

[2] VET ADM MED CTR, DEPT INTERNAL MED, DIV GERIATR, ANN ARBOR, MI 48105 USA

[3] UNIV MICHIGAN, SCH MED, ANN ARBOR, MI 48104 USA

来源：

GERONTOLOGY | 1990年 / 36卷 / 03期

关键词：

Interleukin-1; Malnutrition; Tumor necrosis factor;

D O I：

10.1159/000213193

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Protein malnutrition is associated with a decreased febrile and acute phase response to infection and increased mortality. To elucidate a cause for this poor response, we assessed the effect of chronic protein malnutrition on monocyte production of the pyrogens interleukin-1 (IL-1) and tumor necrosis factor (TNF). Thirteen malnourished nursing home residents, 11 age-matched controls, and 9 young controls were studied. Production of IL-1 and TNF in vitro was not diminished in the malnourished group when compared with the age-matched and young controls. Causes other than diminished IL-1 or TNF production should be sought to explain decreased resistance to infection in the malnourished nursing home resident.

引用

页码：165 / 170

页数：6

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