INHIBITION OF MEDIUM-CHAIN FATTY-ACID BETA-OXIDATION INVITRO BY VALPROIC ACID AND ITS UNSATURATED METABOLITE, 2-NORMAL-PROPYL-4-PENTENOIC ACID

被引：82

作者：

BJORGE, SM ^{[1
]}

BAILLIE, TA ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,BG-20,SEATTLE,WA 98195

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1985年 / 132卷 / 01期

关键词：

D O I：

10.1016/0006-291X(85)91014-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：245 / 252

页数：8

共 30 条

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[2] EFFECT OF 4-PENTENOIC ACID ON FATTY ACID OXIDATION
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[3] BROWNE T R, 1980, New England Journal of Medicine, V302, P661
[4] ACTION OF THE ANTI-EPILEPTIC DRUG, VALPROIC ACID, ON FATTY-ACID OXIDATION IN ISOLATED RAT HEPATOCYTES
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[5] FONG JC, 1978, J BIOL CHEM, V253, P6917
[6] REYE-LIKE SYNDROME ASSOCIATED WITH VALPROIC ACID THERAPY
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[J]. JOURNAL OF PEDIATRICS, 1979, 95 (01) : 142 - 144
[7] PRODUCTION OF FEATURES OF REYES SYNDROME IN RATS WITH 4-PENTENOIC ACID
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[J]. PEDIATRIC RESEARCH, 1975, 9 (03) : 133 - 138
[8] BIOCHEMICAL EFFECTS OF HYPOGLYCEMIC COMPOUND PENT-4-ENOIC ACID AND RELATED NON-HYPOGLYCEMIC FATTY-ACIDS - EFFECTS OF FREE ACIDS AND THEIR CARNITINE ESTERS ON COENZYME-A-DEPENDENT OXIDATIONS IN RAT-LIVER MITOCHONDRIA
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[J]. BIOCHEMICAL JOURNAL, 1973, 136 (01) : 157 - 171
[9] EARLY STRUCTURAL AND FUNCTIONAL-CHANGES IN LIVER OF RATS TREATED WITH A SINGLE DOSE OF VALPROIC ACID
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VENTURINI, C
ORLANDI, F
[J]. HEPATOLOGY, 1984, 4 (06) : 1159 - 1166
[10] THE HEPATOTOXICITY OF VALPROIC ACID AND ITS METABOLITES IN RATS .1. TOXICOLOGIC, BIOCHEMICAL AND HISTOPATHOLOGIC STUDIES
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MACHINIST, JM
[J]. HEPATOLOGY, 1984, 4 (06) : 1143 - 1152

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