MAJOR METABOLITES OF (+/-)3,4-METHYLENEDIOXYAMPHETAMINE (MDA) DO NOT MEDIATE ITS TOXIC EFFECTS ON BRAIN-SEROTONIN NEURONS

被引：42

作者：

MCCANN, UD

RICAURTE, GA

机构：

[1] JOHNS HOPKINS MED INST, DEPT NEUROL, BALTIMORE, MD 21224 USA

[2] WALTER REED ARMY MED CTR, DEPT BEHAV BIOL, WASHINGTON, DC 20307 USA

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

SEROTONIN; NEUROTOXICITY; METHYLENEDIOXYAMPHETAMINE; AMPHETAMINE; ALPHA-METHYLDOPA;

D O I：

10.1016/0006-8993(91)91297-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.

引用

页码：279 / 282

页数：4

共 30 条

[1] MDMA (ECSTASY) EFFECTS ON CULTURED SEROTONERGIC NEURONS - EVIDENCE FOR CA-2+-DEPENDENT TOXICITY LINKED TO RELEASE [J].