TROPHIC EFFECT OF ANGIOTENSIN-II, VASOPRESSIN AND OTHER PEPTIDES ON THE CULTURED VENTRAL SPINAL-CORD OF RAT EMBRYO

被引：34

作者：

IWASAKI, Y ^{[1
]}

KINOSHITA, M ^{[1
]}

IKEDA, K ^{[1
]}

SHIOJIMA, T ^{[1
]}

KURIHARA, T ^{[1
]}

APPEL, SH ^{[1
]}

机构：

[1] BAYLOR UNIV, DEPT NEUROL, HOUSTON, TX 77030 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1991年 / 103卷 / 02期

关键词：

AMYOTROPHIC LATERAL SCLEROSIS; VENTRAL SPINAL CORD CULTURE; ANGIOTENSIN-II; VASOPRESSIN; CHOLECYSTOKININ; OXYTOCIN;

D O I：

10.1016/0022-510X(91)90158-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied trophic effects of angiotensin II, vasopressin, cholecystokinin, and oxytocin on explanted ventral spinal cord cultures from 13- and 14-day-old rat embryos. There was a significant neurite promoting effect of the spinal cord cultures by using angiotensin II, vasopressin, and cholecystokinin. Cholecystokinin had the most potent effect at any concentrations. The minimum effective concentration was 10(-8) M in angiotensin II and vasopressin and 10(-12) M in cholecystokinin, respectively. The effect of angiotensin II and vasopressin was dependent on concentrations. However, the rate and grade of neurite appearance did not correlate with the concentrations of cholecystokinin. Oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II, vasopressin and cholecystokinin have neurotrophic effects on the ventral spinal cord in cultures, and may be candidates for therapeutic trials of amyotrophic lateral sclerosis.

引用

页码：151 / 155

页数：5

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