HTLV-II AMONG ITALIAN INTRAVENOUS-DRUG-USERS AND HEMOPHILIACS

被引：24

作者：

ZANETTI, AR

ZEHENDER, G

TANZI, E

GALLI, C

REZZA, G

CARGNEL, A

BOSCHINI, A

MARI, D

PIZZOCOLO, G

MAZZOTTA, F

CANAVAGGIO, M

LEE, H

机构：

[1] Department of Hygiene, University of Camerino, Camerino, 62032, MC, Viale E. Betti

[2] Institute of Virology, University of Milano

[3] Abbott Diagnostics Division, Roma

[4] Abbott Diagnostics Division, North Cigaco

[5] AIDS Unit - Istituto Superiore di Sanitd, Roma

[6] Infectious Diseases Department, Hospital 'Z. Sacco', Milano

[7] Hemophilia Center, University of Milano

[8] Infectious Diseases, Hospital 'Careggi', Firenze

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 8卷 / 05期

关键词：

EPIDEMIOLOGY; HIV; HTLV-I/II; INTRAVENOUS DRUG USERS; RIPA; WESTERN BLOT;

D O I：

10.1007/BF00145387

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The seroprevalence of HTLV-I/II was evaluated in 1247 Italian individuals at high risk for HIV infection. The population studied consisted of 985 intravenous drug users (IVDUs), 474 of whom on methadone maintenance and 511 in a therapeutic community, 110 HIV-infected patients in various stages of HIV-related disease and 152 hemophiliacs. Sera were screened for antibody to HTLV-I/II by enzyme immunoassay (EIA) and confirmed by Western blot and radioimmunoprecipitation assay. Confirmed positive samples were further differentiated by EIA using HTLV-I and HTLV-II specific peptides. The overall prevalence of anti-HTLV-I/II was 4.0% in IVDUs, with the highest prevalence (8.2%) among HIV-infected symptomatic patients. None of the hemophiliacs was anti-HTLV-I/II positive, even though 63.1% tested positive for HIV antibodies. The trend of seroprevalence in drug users and the evaluation of possible risk factors demonstrated that HTLV-I/II infection has been present in Italy before the onset of HIV epidemic. The overall seroprevalence showed no significant changes during the 10 year period covered by this survey but correlated with HIV seropositivity, age and duration of drug use. Peptide testing showed that HTLV infection was mainly due to HTLV-II.

引用

页码：702 / 707

页数：6

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