SYNTHESIS AND CHROMATOGRAPHIC-SEPARATION OF THE STEREOISOMERS OF FURNIDIPINE

被引：58

作者：

ALAJARIN, R

ALVAREZBUILLA, J

VAQUERO, JJ

SUNKEL, C

DECASAJUANA, MF

STATKOW, PR

SANZAPARICIO, J

机构：

[1] UNIV ALCALA DE HENARES, DEPT QUIM ORGAN, ALCALA DE HENARES, SPAIN

[2] CERMOL S A, GENEVA, SWITZERLAND

[3] CSIC, INST ROCASOLANO, DEPT RAYOS X, E-28006 MADRID, SPAIN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 04期

关键词：

FURNIDIPINE; SYNTHESIS; CHIRAL HPLC; 4; STEREOISOMERS; SEPARATION;

D O I：

10.1016/S0957-4166(00)80162-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase. Enantiomeric purity of stereoisomers is determined by HPLC-CSP technique and configurations deduced via X-ray crystallography.

引用

页码：617 / 620

页数：4

共 18 条

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