A CLINICOPATHOLOGICAL ANALYSIS OF BREAST-CANCER IN PATIENTS WITH A FAMILY HISTORY

被引：26

作者：

FUKUTOMI, T

KOBAYASHI, Y

NANASAWA, T

YAMAMOTO, H

TSUDA, H

机构：

[1] The Department of Surgery, National Cancer Center Hospital, Tokyo, 104, 5-1-1 Tsujiji, Chuo-ku

[2] the Epidemiology Division, National Cancer Center Hospital, Tokyo, 104, 5-1-1 Tsukiji, Chuo-ku

[3] the Pathology Division, National Cancer Center Hospital, Tokyo, 104, 5-1-1 Tsukiji, Chuo-ku

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 10期

关键词：

FAMILY HISTORY; BREAST CANCER; C-ERBB-2; PROGNOSTIC FACTOR;

D O I：

10.1007/BF00311360

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A study was conducted to investigate the clinical and pathological characteristics of breast cancer in patients with a family history (FH). Among 4,481 primary breast cancer patients, 394 (8.8%) had families which included two or more breast cancer patients within three generations (FH(+) group). This group was compared with the remaining 3,969 patients (FH(-) group) with the following results: (1) The tumor diameter in the FH(+) group was slightly less than that in the FH(-) group [not significant (NS)], with fewer lymph node metastases (P < 0.05); (2) the positive rates for the estrogen receptor were 52% (138/266) and 49% (1,216/2,481), respectively (NS); (3) expression of the c-erbB-2 protein was observed in 14 out of 40 (35%) and 32 out of 100 cases (32%), respectively (NS); (4) the relative risk of bilateral occurrence in the FH(+) group was 1.4, with a 95% confidence interval of 0.9-2.4; (5) the 15-year survival rate was 72% and 60%, respectively, suggesting a better prognosis for the FH(+) group (P < 0.01); and (6) multivariate analysis showed that the contribution of FH to postoperative survival was marginal (P = 0.07). Factors related to the hormonal environment such as age at menarche (P = 0.08) and age at menopause (P = 0.08) made a greater but non-significant contribution to the prognosis of the FH(+) group than to that of the FH(-) group. However, further genetic and molecular biological analyses of familial breast cancer are needed in order to clarify the mechanisms of cancer accumulation within families.

引用

页码：849 / 854

页数：6

共 19 条

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