SYNTHESIS OF A GLYCOPEPTIDE CARRYING A N-LINKED CORE PENTASACCHARIDE

被引：63

作者：

MATSUO, I ^{[1
]}

NAKAHARA, Y ^{[1
]}

ITO, Y ^{[1
]}

NUKADA, T ^{[1
]}

NAKAHARA, Y ^{[1
]}

OGAWA, T ^{[1
]}

机构：

[1] RIKEN,INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 11期

关键词：

D O I：

10.1016/0968-0896(95)00139-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A glycopeptide carrying a pentasaccharide core asparagine-linked glycoproteins was synthesized. The synehtesis of the carbohydrate part was performed starting from monosaccharide components in an unambiguous manner. The resultant pentaglycosyl azide was reduced into corresponding glycosyl amine and coupled with an aspartic acid derivative to furnish an Asn-linked dipeptide followed by deprotection gave the target compound.

引用

页码：1455 / 1463

页数：9

共 37 条

[1]

Atherton E, 1989, SOLID PHASE PEPTIDE, P25

[2]

BENZ H, 1994, SYNTHESIS-STUTTGART, P337

[3] A PRACTICAL, CONVERGENT METHOD FOR GLYCOPEPTIDE SYNTHESIS [J].