INCREASES IN PROTEIN-KINASE-C-GAMMA IMMUNOREACTIVITY IN THE SPINAL-CORD DORSAL HORN OF RATS WITH PAINFUL MONONEUROPATHY

被引：83

作者：

MAO, JR ^{[1
]}

PRICE, DD ^{[1
]}

PHILLIPS, LL ^{[1
]}

LU, JA ^{[1
]}

MAYER, DJ ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DIV NEUROSURG, RICHMOND, VA 23298 USA

来源：

NEUROSCIENCE LETTERS | 1995年 / 198卷 / 02期

关键词：

PROTEIN KINASE C GAMMA; HYPERALGESIA; N-METHYL-D-ASPARTATE; IMMUNOCYTOCHEMISTRY; NERVE INJURY; NEUROPATHIC PAIN;

D O I：

10.1016/0304-3940(95)11975-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Eight days after chronic constrictive sciatic nerve injury (CCI), protein kinase C gamma (PKC gamma) immunoreactivity reliably increased in the spinal cord dorsal horn of CCI rats with demonstrable thermal hyperalgesia as compared to sham-operated controls. Such PKC gamma immunostaining was observed primarily in neuronal somata (ipsilateral > contralateral, laminae I-II > III-IV), indicating post-synaptic sites of PKC gamma increases. Both the development of thermal hyperalgesia and the increase in PKC gamma immunoreactivity in CCI rats were prevented by once daily intrathecal administration with 10 nmol MK-801 for 7 days. The present results provide further evidence for-a role of PKC in N-methyl-D-aspartate (NMDA) receptor-mediated mechanisms of thermal hyperalgesia.

引用

页码：75 / 78

页数：4

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