CORRELATION BETWEEN RELEASE OF FREE ARACHIDONIC-ACID AND PROSTAGLANDIN FORMATION IN BRAIN CORTEX AND CEREBELLUM

被引：95

作者：

BOSISIO, E

GALLI, C

GALLI, G

NICOSIA, S

SPAGNUOLO, C

TOSI, L

机构：

[1] UNIV MILAN, INST PHARMACOL & PHARMACOGNOSY, I-20129 MILAN, ITALY

[2] UNIV MILAN, APPL BIOCHEM LAB, I-20129 MILAN, ITALY

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1976年 / 11卷 / 05期

关键词：

D O I：

10.1016/0090-6980(76)90186-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Levels of free arachidonic acid and of prostaglandin [PGF2.alpha.] and PGE2 measured in both brain cortex and cerebellum of rats killed by focussed microwave irradiation, and after decapitation followed by ischemia. The same parameters were studied during incubation assays. After ischemia levels of both free arachidonic acid and of PG in cerbellum are lower than in brain cortex, formation of PG from endogenous precursor in incubated cortex is higher than in cerebellum, release of free arachidonic acid occurs mainly during the time interval between the sacrifice of the animals and the beginning of the incubation; PG are formed mainly during the incubation assay. The correlation between release of free arachidonic acid and PG formation is discussed.

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页码：773 / 781

页数：9

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