INVITRO REGULATION OF B-CELL DIFFERENTIATION BY INTERLEUKIN-6 AND SOLUBLE CD23 IN SYSTEMIC LUPUS-ERYTHEMATOSUS B-CELL SUBPOPULATIONS AND ANTIGEN-INDUCED NORMAL B-CELLS

被引：49

作者：

KLASHMAN, DJ

MARTIN, RA

MARTINEZMAZA, O

STEVENS, RH

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT GYNECOL ONCOL,LOS ANGELES,CA 90024

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 03期

关键词：

D O I：

10.1002/art.1780340305

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL-6 antibodies inhibited immunoglobulin production in cultures of normal and SLE B cells, which suggests that IL-6 is required for B cell differentiation. SLE culture supernatants had elevated levels of IL-6, which explains the poor response of the SLE cells to exogenous IL-6. normal subjects and SLE patients.

引用

页码：276 / 286

页数：11

共 48 条

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