GENOTOXICITY OF 2,4,6-TRICHLOROPHENOL IN V79 CHINESE-HAMSTER CELLS

被引：15

作者：

JANSSON, K ^{[1
]}

JANSSON, V ^{[1
]}

机构：

[1] UNIV JYVASKYLA,DEPT CELL BIOL,SF-40100 JYVASKYLA,FINLAND

来源：

MUTATION RESEARCH | 1992年 / 280卷 / 03期

关键词：

CHLOROPHENOLS; 2,4,6-TRICHLOROPHENOL; CARCINOGENS; ENVIRONMENTAL; MUTAGENICITY TESTS; CELLS; CULTURED;

D O I：

10.1016/0165-1218(92)90046-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxicity of the rodent carcinogen 2,4,6-trichlorophenol (TCP) was studied without exogenous metabolic activation in V79 Chinese hamster cells. TCP did not induce mutation at the hprt locus to 6-thioguanine resistance or structural chromosome aberrations. However, it produced statistically significant, dose-related increases in hyperdiploidy and micronuclei. From these results it appears that TCP causes chromosome malsegregation as its major mode of genotoxic action.

引用

页码：175 / 179

页数：5

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