EFFECT OF BENOMYL TOXICITY ON SOME LIVER CONSTITUENTS OF ALBINO-RATS

Weanling albino rats were fed 0-600 mg/kg body weight methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl) for 7 d, and effects on protein, glycogen, and vitamin A constituents were recorded. Doses fed in rat chow were 0, 40, 80, 125, 165, 200, 240, 280, 320, 360, 400, 440, 480, 520, 560, and 600 mg/kg body weight. There was a dose-dependent decrease in the concentration of liver constituents, of which glycogen decreased the most. Histopathological findings included cellular swelling and edema of the liver, kidney, and spleen.