ACTIVITY AGAINST TRYPANOSOMA-CRUZI OF NEW ANALOGS OF NIFURTIMOX

被引：30

作者：

MESTER, B

ELGUERO, J

CLARAMUNT, RM

CASTANYS, S

MASCARO, ML

OSUNA, A

VILAPLANA, MJ

MOLINA, P

机构：

[1] UNIV NACL EDUC DISTANCIA, FAC CIENCIAS, E-28040 MADRID, SPAIN

[2] FAC FARM GRANADA, DEPT PARASITOL, E-18001 GRANADA, SPAIN

[3] FAC CIENCIAS MURCIA, DEPT QUIM ORGAN, E-30001 MURCIA, SPAIN

来源：

ARCHIV DER PHARMAZIE | 1987年 / 320卷 / 02期

关键词：

D O I：

10.1002/ardp.19873200205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten new derivatives 1 structurally related to Nifurtimox have been synthesized from 5-nitrofurfural and the corresponding N-aminoheterocyclic compounds. Physical data, spectroscopic characteristics and biological properties have been examined. An unusual long-range coupling constant in the pyrazolyl derivative 1b has been observed. Compounds in which the heterocyclic counterparts are 1,2,4-triazol-4-yl and pyridin-1-yl groups clearly show superior activity against Trypanosoma cruzi.

引用

页码：115 / 120

页数：6

共 15 条

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ADGER BM, 1975, J CHEM SOC PERK T 1, P31, DOI 10.1039/p19750000031

[2] AROMATIC SYSTEMS WITH 10-PI ELECTRONS DERIVED FROM 3A-AZAPENTALENE .40. STUDIES ON THE 1,2,4-TRIAZOLO[4,3-B][1,2,4]TRIAZOLE SERIES [J].