REGIONAL MYOCARDIAL BLOOD-VOLUME AND FLOW - FIRST-PASS MR-IMAGING WITH POLYLYSINE-GD-DTPA

被引：127

作者：

WILKE, N

KROLL, K

MERKLE, H

WANG, Y

ISHIBASHI, Y

XU, Y

ZHANG, JN

JEROSCHHEROLD, M

MUHLER, A

STILLMAN, AE

BASSINGTHWAIGHTE, JB

BACHE, R

UGURBIL, K

机构：

[1] UNIV MINNESOTA,DEPT RADIOL,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DIV CARDIOVASC,MINNEAPOLIS,MN 55455

[3] UNIV WASHINGTON,CTR BIOENGN,SEATTLE,WA 98195

[4] SCHERING AG,W-1000 BERLIN,GERMANY

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1995年 / 5卷 / 02期

关键词：

CONTRAST AGENT; BLOOD POOL; CONTRAST ENHANCEMENT; CORONARY VESSELS; DISEASES; HEART; FLOW DYNAMICS; MODEL; MATHEMATICAL; MYOCARDIUM; BLOOD SUPPLY; PERFUSION STUDIES;

D O I：

10.1002/jmri.1880050219

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The authors investigated the utility of an intravascular magnetic resonance [MR] contrast agent, poly-L-lysine-gadolinium diethylenetriaminepentaacetic acid (DTPA), for differentiating acutely ischemic from normally perfused myocardium with first-pass MR imaging. Hypoperfused regions, identified with microspheres, on the first-pass images displayed significantly decreased signal intensities compared with normally perfused myocardium (P < .0007). Estimates of regional myocardial blood content, obtained by measuring the ratio of areas under the signal intensity-versus-time curves in tissue regions and the left ventricular chamber, averaged 0.12 mL/g +/- 0.04 (n = 35), compared with a value of 0.11 mL/g +/- 0.05 measured with radiolabeled albumin in the same tissue regions. To obtain MR estimates of regional myocardial blood flow, in situ calibration curves were used to transform first-pass intensity-time curves into content-time curves for analysis with a multiple-pathway, axially distributed model. Flow estimates, obtained by automated parameter optimization, averaged 1.2 ml/min/g +/- 0.5 (n = 29), compared with 1.3 ml/min/g +/- 0.3 obtained with tracer microspheres in the same tissue specimens at the same time. The results represent a combination of T1-weighted first-pass imaging, intravascular relaxation agents, and a spatially distributed perfusion model to obtain absolute regional myocardial blood flow and volume.

引用

页码：227 / 237

页数：11

共 38 条

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