IDENTIFICATION OF NEURONAL PROGRAMMED CELL-DEATH IN-SITU IN THE STRIATUM OF NORMAL ADULT-RAT BRAIN AND ITS RELATIONSHIP TO NEURONAL DEATH DURING AGING

被引：51

作者：

ZHANG, L

KOKKONEN, G

ROTH, GS

机构：

[1] Molecular Physiology and Genetics Section, Gerontology Research Center, NIA, Francis Scott Key Medical Center, GRC Bldg, Rm. 4E18, NIA/NIH, 4940 Eastern Avenue, Baltimore

来源：

BRAIN RESEARCH | 1995年 / 677卷 / 01期

关键词：

PROGRAMMED CELL DEATH; STRIATUM; AGING;

D O I：

10.1016/0006-8993(95)00197-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptotic neurons have been identified in normal adult rat striatum by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling technique. This observation suggests that neuronal programmed cell death starts at an early stage of adult life and may contribute to the aging associated neuronal loss. In addition, the frequency of apoptotic cells was found to significantly increase in old rats, which implies that aging itself accelerates the process.

引用

页码：177 / 179

页数：3

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