CEFEPIME CONCENTRATIONS IN BRONCHIAL-MUCOSA AND SERUM FOLLOWING A SINGLE 2 GRAM INTRAVENOUS DOSE

被引：23

作者：

CHADHA, D ^{[1
]}

WISE, R ^{[1
]}

BALDWIN, DR ^{[1
]}

ANDREWS, JM ^{[1
]}

ASHBY, JP ^{[1
]}

HONEYBOURNE, D ^{[1
]}

机构：

[1] DUDLEY RD GEN HOSP,DEPT MED MICROBIOL,BIRMINGHAM B18 7QH,W MIDLANDS,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1990年 / 25卷 / 06期

关键词：

D O I：

10.1093/jac/25.6.959

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The concentrations of cefepime in bronchial mucosa were measured after intravenous administration of a single 2 g dose in 20 patients undergoing diagnostic fibreoptic bronchoscopy. These concentrations were compared with simultaneous serum concentrations. The mean bronchial mucosal concentration was 24.1 mg/kg (S.D. 17.8 mg/kg) and the mean serum concentration was 40.4 mg/1 (s.d. 28.1 mg/1). The mean percentage penetration was 59.8% (s.d. 12.5%). We conclude that a twice daily dosing of cefepime would be adequate for most respiratory infections although an 8-hourly dose may be necessary in pseudomonal infections. © 1990 The British Society for Antimicrobial Chemotherapy.

引用

页码：959 / 963

页数：5

共 17 条

[1] INVITRO STUDIES OF BMY-28142, A NEW BROAD-SPECTRUM CEPHALOSPORIN [J].

BODEY, GP ;

HO, DH ;

LEBLANC, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (02) :265-269

[2] EVALUATION OF THE INVITRO ACTIVITY OF BMY-28142, A NEW BROAD-SPECTRUM CEPHALOSPORIN [J].

FUCHS, PC ;

JONES, RN ;

BARRY, AL ;

THORNSBERRY, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (05) :679-682

[3] THE MUCOSAL EPITHELIUM OF THE RESPIRATORY TRACT IN MUCO-PURULENT BRONCHITIS CAUSED BY HAEMOPHILUS-INFLUENZAE [J].

HERS, JFP ;

MULDER, J .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1953, 66 (01) :103-&

[4] EVALUATION OF THE PENETRATION OF CIPROFLOXACIN AND AMOXYCILLIN INTO THE BRONCHIAL-MUCOSA [J].

HONEYBOURNE, D ;

ANDREWS, JM ;

ASHBY, JP ;

LODWICK, R ;

WISE, R .

THORAX, 1988, 43 (09) :715-719

[5] COMPARISON OF A NEW CEPHALOSPORIN, BMY 28142, WITH OTHER BROAD-SPECTRUM BETA-LACTAM ANTIBIOTICS [J].

KESSLER, RE ;

BIES, M ;

BUCK, RE ;

CHISHOLM, DR ;

PURSIANO, TA ;

TSAI, YH ;

MISIEK, M ;

PRICE, KE ;

LEITNER, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 27 (02) :207-216

[6] ANTIMICROBIAL ACTIVITIES OF BMY-28142, CEFBUPERAZONE, AND CEFPIRAMIDE COMPARED WITH THOSE OF OTHER CEPHALOSPORINS [J].

KHAN, NJ ;

BIHL, JA ;

SCHELL, RF ;

LEFROCK, JL ;

WEBER, SJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 26 (04) :585-590

[7] EFFICACY OF BMY-28142 IN EXPERIMENTAL BACTEREMIA AND MENINGITIS CAUSED BY ESCHERICHIA-COLI AND GROUP-B STREPTOCOCCI [J].

KIM, KS ;

BAYER, AS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (01) :51-54

[8] PENETRATION OF CEFACLOR INTO BRONCHIAL-MUCOSA [J].

MARLIN, GE ;

NICHOLLS, AJ ;

FUNNELL, GR ;

BRADBURY, R .

THORAX, 1984, 39 (11) :813-817

[9]

MARLIN GE, 1986, AM REV RESPIR DIS, V134, P1209

[10]

NEU H C, 1983, Reviews of Infectious Diseases, V5, pS319

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