SYNTHESIS AND BIODISTRIBUTION OF A NEW CLASS OF TC-99M-LABELED FATTY-ACID ANALOGS FOR MYOCARDIAL IMAGING

被引：31

作者：

MACH, RH ^{[1
]}

KUNG, HF ^{[1
]}

JUNGWIWATTANAPORN, P ^{[1
]}

GUO, YZ ^{[1
]}

机构：

[1] UNIV PENN,DEPT RADIOL,DIV NUCL MED,PHILADELPHIA,PA 19104

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1991年 / 18卷 / 02期

关键词：

D O I：

10.1016/0883-2897(91)90082-V

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A series of 99mTc-bis(aminoethanethiol)-fatty acid (99mTc-BAT-fatty acid) analogs were synthesized and evaluated as potential tracers of myocardial metabolism. The BAT-fatty acid precursors were prepared using a new synthetic route that avoids the use of strong reducing agents such as lithium aluminum hydride. Biodistribution studies of the no-carrier-added 99mTc-complexes were conducted in rats using [I-125]IPPA as an internal standard. The myocardial uptake of the 99mTc-BAT-fatty acid analogs was significantly less than that of [I-125]IPPA and indicates the 99mTc analogs are not suitable candidates for SPECT-based myocardial imaging studies.

引用

页码：215 / 226

页数：12

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