CHANGES OF THE SUBSARCOLEMMAL NA+ CONCENTRATION IN INTERNALLY PERFUSED CARDIAC-CELLS

被引：55

作者：

BIELEN, FV ^{[1
]}

GLITSCH, HG ^{[1
]}

VERDONCK, F ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, INTERDISCIPLINARY RES CTR, CAMPUS KORTRIJK, KORTRIJK, BELGIUM

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1065卷 / 02期

关键词：

ION DISTRIBUTION; DIALYZED CELL; WHOLE-CELL RECORDING; SODIUM POTASSIUM PUMP CURRENT; SODIUM CALCIUM EXCHANGE CURRENT;

D O I：

10.1016/0005-2736(91)90239-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transients of Na+/K+ pump and of Na+/Ca2+ exchange current occur during whole-cell recording from cardiac cells upon quick changes of active Na+ efflux. The transients reflect a temporary loss of control of the subsarcolemmal Na+ concentration. Even in the steady state the control is not complete is certain cells. Quantitative studies on ion transport by whole-cell recording are meaningful only if an adequate control of the submembranal ionic composition is demonstrated.

引用

页码：269 / 271

页数：3

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