(N-[C-11]-METHYL)DOXEPIN - SYNTHESIS OF A RADIOTRACER FOR STUDYING THE HISTAMINE H-1 RECEPTOR

被引：7

作者：

RAVERT, HT ^{[1
]}

DANNALS, RF ^{[1
]}

WILSON, AA ^{[1
]}

WAGNER, HN ^{[1
]}

机构：

[1] JOHNS HOPKINS MED INST,DIV RADIAT HLTH SCI,BALTIMORE,MD 21205

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 05期

关键词：

DOXEPIN; C-11; HISTAMINE; POSITRON EMISSION TOMOGRAPHY;

D O I：

10.1002/jlcr.2580310510

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Doxepin (3-dibenz [b,e] oxepin - .11(6H) - ylidene - N,N - dimethyl - 1-propanamine), a potent H-1 histamine antagonist, was labeled with C-11-iodomethane by N-alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/mu-mol (EOS).

引用

页码：403 / 407

页数：5